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These drugs disrupt the autocrine and paracrine signaling pathways between these cells, ultimately resulting in alterations to cardiac cell homeostasis ( 4.3.2 Doxorubicin Doxorubicin (DOX), a widely employed chemotherapeutic agent, is nonetheless limited in its clinical application due to its significant cardiotoxicity

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All three are GH secretagogues that activate the GHS-R1a receptor, but they differ in selectivity: The choice depends on the research protocol: selectivity (ipamorelin), power (GHRP-2) or orexigenic effect (GHRP-6)

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In experimental settings: When combined, these peptides allow researchers to investigate overlapping and complementary signaling behaviors across multiple biological systems